Ly49h is necessary for genetic resistance to murine cytomegalovirus

Murine Cytomegalovirus Is Regulated by a Discrete Subset of Natural Killer Cells Reactive with Monoclonal Antibody to Ly49h

Antiviral roles of natural killer (NK) cell subsets were examined in C57BL/6 mice infected with murine cytomegalovirus (MCMV) and other viruses, including lymphocytic choriomeningitis virus (LCMV), vaccinia virus (VV), and mouse hepatitis virus (MHV). Each virus vigorously induced an NK cell infiltrate into the peritoneal cavity and liver, causing some redistributions of NK cell subsets defined...

Ly49H signaling through DAP10 is essential for optimal natural killer cell responses to mouse cytomegalovirus infection

The activating natural killer (NK) cell receptor Ly49H recognizes the mouse cytomegalovirus (MCMV) m157 glycoprotein expressed on the surface of infected cells and is required for protection against MCMV. Although Ly49H has previously been shown to signal via DAP12, we now show that Ly49H must also associate with and signal via DAP10 for optimal function. In the absence of DAP12, DAP10 enables ...

effects of macrophages in resistance to murine cytomegalovirus infection

in a preliminary experiment. the protective effects of ' peritoneal macrophages was shown by transferring macroph. ages fr-om adult mice to newborn and to 7 and 14 days old mice. it suckling mice from intraperitoneal infection with mcmv by reducing the mortality rate from 100% to 27%.was demontrated that such transplentatton protect

Murine Cytomegalovirus Infection Stimulating NK Cell Proliferation During Absence of Type I Interferon Signaling in Ly49H Engagement Compensates for the

Is Resistance Training to Muscular Failure Necessary?

Resistance training (RT) is the main method of exercise for improving strength and skeletal muscle mass (i.e., muscle hypertrophy; ACSM, 2009). In order to promote such adaptations, high-intensity resistance training (HI-RT) with loads above 60% of one repetition maximum (1-RM) are typically recommended (ACSM, 2009). To further maximize increases in strength and muscle hypertrophy, it has been ...